According to the actress, 38, most of the singer's followers are "true champions of kindness" and she doesn't understand hateful comments about her in the new issue of Rolling Stone magazine.
During the interview, Styles admitted that spiteful comments about mum-of-two Wilde "obviously" do not make him "feel good" about himself.
"What I don't understand about the cruelty you're referencing is that that kind of toxic negativity is the antithesis of everything Harry represents.
His fan base is not defined by the hateful energy, in my opinion. Most of them are true champions of kindness."
They first met on the set of Olivia's upcoming film, "Don't Worry Darling", starring the ex-One Direction member, after meeting at Jeffrey Azoff's wedding in January 2021.
A custody battle is still underway between Wilde and her ex, actor Jason Sudeikis, 46, with whom she shares two children, son Otis, eight, and daughter Daisy, five.
During the interview, in which he wore gender-fluid feathers and fur outfits, Styles said he tries not to discuss life "away from work" or to correct media reports.
I strongly believe that if someone takes a picture of you with someone, it doesn't mean you are choosing to have a public relationship with them or anything of the sort."
In addition, Styles confessed to dreading the thought of telling potential partners that they may be exposed to gossip and attacks through nasty corners of social media.
“Can you imagine going on a second date and being like, ‘There's that corner, and it's going to be crazy, and it's going to be mean, and it's not real, but anyway, what do you want to eat?’”